Journal article
Peroxide resistance of ER Ca2+ pump in endothelium: implications to coronary artery function
Abstract
We examined the effects of peroxide on the sarco(endo)plasmic reticulum Ca2+ (SERCA) pump in pig coronary artery endothelium and smooth muscle at three organizational levels: Ca2+ transport in permeabilized cells, cytosolic Ca2+ concentration in intact cells, and contractile function of artery rings. We monitored the ATP-dependent, azide-insensitive, oxalate-stimulated 45Ca2+ uptake by saponin-permeabilized cultured cells. Low concentrations of …
Authors
Grover AK; Samson SE
Journal
American Journal of Physiology, Vol. 273, No. 4, pp. c1250–c1258
Publisher
American Physiological Society
Publication Date
October 1, 1997
DOI
10.1152/ajpcell.1997.273.4.c1250
ISSN
0002-9513