Journal article
Effects of Cytochrome P450 Inhibitors on the Biotransformation of Fluorogenic Substrates by Adult Male Rat Liver Microsomes and cDNA-Expressed Rat Cytochrome P450 Isoforms
Abstract
We have evaluated the use of a panel of six fluorogenic cytochrome P450 (CYP) substrates as a potential tool for rapid screening for global changes in CYP activity in rats under different physiological conditions. The biotransformation of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC), 7-benzyloxy-4-(trifluoromethyl)-coumarin, 7-benzyloxyquinoline, 3-cyano-7-ethoxycoumarin, 7-methoxy-4-(trifluoromethyl)-coumarin, …
Authors
Makaji E; Trambitas CS; Shen P; Holloway AC; Crankshaw DJ
Journal
Toxicological Sciences, Vol. 113, No. 2, pp. 293–304
Publisher
Oxford University Press (OUP)
Publication Date
February 1, 2010
DOI
10.1093/toxsci/kfp255
ISSN
1096-6080