Journal article
Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
Abstract
BACKGROUND AND PURPOSE: Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated.
EXPERIMENTAL APPROACH: Aortic rings from Wistar rats were prepared with both PVAT and E intact (PVAT+ E+), with either PVAT or E removed (PVAT- E+, or PVAT+ E-), or with both removed (PVAT- E-) for functional studies. …
Authors
Gao Y; Lu C; Su L; Sharma AM; Lee RMKW
Journal
British Journal of Pharmacology, Vol. 151, No. 3, pp. 323–331
Publisher
Wiley
Publication Date
June 2007
DOI
10.1038/sj.bjp.0707228
ISSN
0007-1188
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipose TissueAdrenergic alpha-AgonistsAnimalsAorta, ThoracicDose-Response Relationship, DrugEndothelium, VascularEnzyme InhibitorsGuanylate CyclaseHydrogen PeroxideIn Vitro TechniquesMaleMuscle, Smooth, VascularNitric Oxide DonorsNitric Oxide SynthaseNitroargininePhenylephrinePotassium Channel BlockersPotassium ChannelsRatsRats, WistarSerotoninTetraethylammoniumVasoconstrictionVasodilation