Journal article
DNA methyltransferase inhibitors—state of the art
Abstract
BACKGROUND: DNA methylation is the addition of a methyl group to the 5 position of cytosine. It is an epigenetic process with several effects, including chromatin structure modulation, transcriptional repression and the suppression of transposable elements. In malignancy, methylation patterns change, resulting in global hypomethylation with regional hypermethylation. This can lead to genetic instability and the repression of tumor suppressor …
Authors
Goffin J; Eisenhauer E
Journal
Annals of Oncology, Vol. 13, No. 11, pp. 1699–1716
Publisher
Elsevier
Publication Date
November 2002
DOI
10.1093/annonc/mdf314
ISSN
0923-7534
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBase SequenceClinical Trials, Phase II as TopicDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA, NeoplasmEnzyme InhibitorsFemaleGene Expression RegulationHumansLymphomaMaleMethyltransferasesMolecular Sequence DataNeoplasmsPolymerase Chain ReactionPrognosisSensitivity and SpecificityTreatment Outcome