Antioxidant responses and oxidative stress after microcystin exposure in the hepatopancreas of an estuarine crab species Journal Articles uri icon

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  • Antioxidant responses and oxidative stress were evaluated in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Brachyura) after oral microcystin administration. Responses were evaluated through antioxidant enzyme activities (catalase-(CAT), superoxide dismutase, glutathione-S-transferase- (GST)). Nonproteic sulfhydril (NP-SH) groups, oxygen consumption, lipid peroxides (LPO), and oxidized proteins were also measured. Microcystin administration increased the oxygen consumption. GST activity and NP-SH concentration showed transient increases and CAT activity showed a peak and then a reduction. Oxidative damage was evidenced with regard to LPO content and suggested by the inhibition of CAT activity at the end of the experiment, indicating that the antioxidant response induced by the toxin was insufficient. A lowering in the number of hepatopancreatic B cells should be related to microcystin elimination.


  • Pinho, GLL
  • Moura da Rosa, C
  • Maciel, FE
  • Bianchini, Adalto
  • Yunes, JS
  • Proença, LAO
  • Monserrat, JM

publication date

  • July 2005