Journal article
SRF‐dependent gene expression is required for PI3‐kinase‐regulated cell proliferation
Abstract
Recent evidence indicates that phosphatidylinositol 3‐kinase (PI3K) is a central regulator of mitosis, apoptosis and oncogenesis. Nevertheless, the mechanisms by which PI3K regulates proliferation are not well characterized. Mitogens stimulate entry into the cell cycle by inducing the expression of immediate early genes (IEGs) that in turn trigger the expression of G1 cyclins. Here we describe a novel PI3K‐ regulated transcriptional cascade …
Authors
Poser S; Impey S; Trinh K; Xia Z; Storm DR
Journal
The EMBO Journal, Vol. 19, No. 18, pp. 4955–4966
Publisher
Springer Nature
Publication Date
September 15, 2000
DOI
10.1093/emboj/19.18.4955
ISSN
0261-4189
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3T3 CellsAndrostadienesAnimalsBlotting, WesternCell CycleCell DivisionCell SeparationChromonesDNA-Binding ProteinsDose-Response Relationship, DrugEnzyme ActivationEnzyme InhibitorsFlow CytometryGTP-Binding ProteinsGene Expression Regulation, EnzymologicGenes, DominantHeLa CellsHumansImmunohistochemistryLac OperonLuciferasesMiceMitogen-Activated Protein KinasesMorpholinesMutagenesis, Site-DirectedNerve Growth FactorNuclear ProteinsPC12 CellsPhosphatidylinositol 3-KinasesPhosphorylationPlasmidsProto-Oncogene Proteins c-fosRatsReceptor, Platelet-Derived Growth Factor betaReverse Transcriptase Polymerase Chain ReactionSerum Response FactorSignal TransductionTranscription FactorsTranscription, GeneticTranscriptional ActivationTransfectionWortmanninp38 Mitogen-Activated Protein Kinasesrho GTP-Binding Proteins