Journal article
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions
Abstract
BACKGROUND: Food anaphylaxis is an acute and life-threatening systemic allergic reaction. Fatality registries place peanut as the most common culprit of fatal and near-fatal reactions in North America. Because prophylaxis and treatment have advanced little in recent years, it is imperative to evaluate novel therapies.
OBJECTIVE: To investigate the impact of blocking mast cell mediators in a mouse model of peanut-induced anaphylaxis.
Authors
Arias K; Baig M; Colangelo M; Chu D; Walker T; Goncharova S; Coyle A; Vadas P; Waserman S; Jordana M
Journal
The Journal of Allergy and Clinical Immunology, Vol. 124, No. 2, pp. 307–314.e2
Publisher
Elsevier
Publication Date
8 2009
DOI
10.1016/j.jaci.2009.03.012
ISSN
0091-6749
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AllergensAnaphylaxisAnimalsArachisCholera ToxinCimetidineDisease Models, AnimalDrug Therapy, CombinationEnzyme InhibitorsFemaleHistamineHistamine AntagonistsHistamine H1 AntagonistsHydroxyureaImmunoglobulin EImmunoglobulin GLipoxygenase InhibitorsMiceMice, Inbred C57BLPeanut HypersensitivityPlatelet Membrane GlycoproteinsPyrilamineReceptors, G-Protein-CoupledReceptors, Histamine