Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoproteinā€Associated Phospholipase Inhibitors Journal Articles uri icon

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abstract

  • EXPANDING OUR KNOWLEDGE: Natural lipocyclocarbamate natural products have provided the inspiration for the first-in-class synthetic phospholipase inhibitor darapladib, currently in phase III clinical trials for the treatment of atherosclerosis. Here, we discuss their biosynthesis by a nonribosomal peptide synthetase.

publication date

  • March 4, 2013