Journal article
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
Abstract
Individual variation in pain sensation makes pain clinical trials quite challenging to interpret. Now, Michael Salter and colleagues report that genetic variation in the P2RX7 gene affects pore formation of the protein and pain sensation in humans.
Authors
Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin J-S; Zaykin DV; Meulen HV; Costigan M
Journal
Nature Medicine, Vol. 18, No. 4, pp. 595–599
Publisher
Springer Nature
Publication Date
4 2012
DOI
10.1038/nm.2710
ISSN
1078-8956
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateAnimalsBenzoxazolesCalciumCarbenoxoloneCells, CulturedChronic PainCohort StudiesConnexinsDisease Models, AnimalEnzyme InhibitorsFemaleGenetic LinkageGenome-Wide Association StudyGenotypeHistidineHumansHyperalgesiaMacrophagesMaleMastectomyMiceMice, Inbred StrainsMutationNerve Tissue ProteinsOsteoarthritisPain MeasurementPain ThresholdPeptidesPolymorphism, Single NucleotideQuinolinium CompoundsReceptors, Purinergic P2X7Retrospective StudiesSpecies SpecificityTime FactorsTransfection