Journal article
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
Abstract
Cell cycle regulatory proteins are important candidates for therapeutic tumour suppressors. Adenovirus vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter. These vectors directed the efficient expression of each of the cyclin kinase inhibitors and induced growth arrest, inhibited DNA synthesis, and …
Authors
Schreiber M; Muller WJ; Singh G; Graham FL
Journal
Oncogene, Vol. 18, No. 9, pp. 1663–1676
Publisher
Springer Nature
Publication Date
March 4, 1999
DOI
10.1038/sj.onc.1202466
ISSN
0950-9232
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenocarcinomaAdenoviruses, HumanAnimalsApoptosisBlotting, WesternCarcinogenicity TestsCarrier ProteinsCell CycleCell Cycle ProteinsCell DivisionCell Line, TransformedCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18Cyclin-Dependent Kinase Inhibitor p19Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsEnzyme InhibitorsGenetic VectorsHeLa CellsHumansMammary Neoplasms, ExperimentalMicrotubule-Associated ProteinsPhosphorylationRetinoblastoma ProteinTransgenesTumor Suppressor Proteins