Journal article
Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
Abstract
OBJECTIVES: Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS).
METHODS AND RESULTS: In Wistar-Kyoto rats, rings of superior mesenteric artery (MA) with intact PVAT (PVAT (+)) showed a greater contractile response to EFS than rings …
Authors
Gao Y-J; Takemori K; Su L-Y; An W-S; Lu C; Sharma AM; Lee RMKW
Journal
Cardiovascular Research, Vol. 71, No. 2, pp. 363–373
Publisher
Oxford University Press (OUP)
Publication Date
July 15, 2006
DOI
10.1016/j.cardiores.2006.03.013
ISSN
0008-6363
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipose TissueAngiotensin IIAnimalsButadienesCyclooxygenase InhibitorsDose-Response Relationship, DrugElectric StimulationEnzyme InhibitorsImmunohistochemistryIn Vitro TechniquesMaleMesenteric ArteriesMitogen-Activated Protein KinasesMuscle, Smooth, VascularNADH, NADPH OxidoreductasesNADPH OxidasesNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitrilesPhenylephrineProtein-Tyrosine KinasesRatsRats, Inbred SHRReverse Transcriptase Polymerase Chain ReactionSuperoxide DismutaseSuperoxidesTyrphostinsVasoconstriction