Journal article
Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
Abstract
Cyclopiazonic acid (CPA) is a sarcoplasmic reticulum Ca2+-ATPase inhibitor that increases intracellular calcium. The role of CPA in regulating the oxidation and esterification of palmitate, the hydrolysis of intramuscular lipids, and the activation of hormone-sensitive lipase (HSL) was examined in isolated rat soleus muscles at rest. CPA (40 micro M) was added to the incubation medium to levels that resulted in subcontraction increases in …
Authors
Watt MJ; Steinberg GR; Heigenhauser GJF; Spriet LL; Dyck DJ
Journal
AJP Endocrinology and Metabolism, Vol. 285, No. 2, pp. e412–e419
Publisher
American Physiological Society
Publication Date
August 2003
DOI
10.1152/ajpendo.00023.2003
ISSN
0193-1849
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBenzylaminesCaffeineCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCalcium-Transporting ATPasesEnzyme ActivationEnzyme InhibitorsEsterificationFemaleHydrolysisIndolesLipid MetabolismMuscle ContractionMuscle, SkeletalOxidation-ReductionPalmitic AcidPhospholipidsRatsRats, Sprague-DawleySterol EsteraseSulfonamidesTriglycerides