Journal article
Effects of geldanamycin on HIF-1α mediated angiogenesis and invasion in prostate cancer cells
Abstract
Geldanamycin (GA), a benzoquinone ansamycin, is a naturally occurring inhibitor of heat shock protein (Hsp90), which regulates the transcription activity of hypoxia-inducible factor 1 (HIF-1α). Under hypoxia, HIF-1α is activated in tumor cells, and induces the transcription of vascular endothelial growth factor (VEGF), which is the prime regulator for angiogenesis. VEGF promotes the formation of new blood vessels by stimulating endothelial cell …
Authors
Alqawi O; Moghaddas M; Singh G
Journal
Prostate Cancer and Prostatic Diseases, Vol. 9, No. 2, pp. 126–135
Publisher
Springer Nature
Publication Date
June 1, 2006
DOI
10.1038/sj.pcan.4500852
ISSN
1365-7852
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
BenzoquinonesBlotting, NorthernCell HypoxiaCell Line, TumorCell MovementEnzyme InhibitorsEnzyme-Linked Immunosorbent AssayHumansHypoxia-Inducible Factor 1, alpha SubunitLactams, MacrocyclicMaleMetalloproteasesNeovascularization, PathologicProstatic NeoplasmsQuinonesRNA, MessengerReference ValuesReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTranscription FactorsVascular Endothelial Growth Factor A