Journal article
Regulation of plasminogen activator inhibitor‐1 secretion by urokinase and tissue plasminogen activator in rat epithelioid‐type smooth muscle cells
Abstract
Tissue plasminogen activator (tPA) and urokinase (uPA) are targets of plasminogen activator inhibitor-1 (PAI-1) inhibition. We have previously shown that both proteases can also induce PAI-1 secretion in rat smooth muscle cells (SMCs). We now report that both proteases appear to use very similar cellular mechanisms for signal transduction. They induced PAI-1 secretion using a pathway(s) involving protein kinase C (PKC). They also activated the …
Authors
Lau HKF; Ho J
Journal
British Journal of Haematology, Vol. 117, No. 1, pp. 151–158
Publisher
Wiley
Publication Date
4 2002
DOI
10.1046/j.1365-2141.2002.03402.x
ISSN
0007-1048
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsBucladesineCarbazolesCells, CulturedCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsFlavonoidsGenisteinIndolesIsoquinolinesMAP Kinase Signaling SystemMuscle, Smooth, VascularPhosphodiesterase InhibitorsPhosphorylationPlasminogen Activator Inhibitor 1Protein Kinase CProtein-Tyrosine KinasesPyrrolesRatsSignal TransductionStilbenesSulfonamidesTissue Plasminogen ActivatorUrokinase-Type Plasminogen Activatorsrc-Family Kinases