Journal article
Effects of peroxynitrite on pig coronary artery smooth muscle
Abstract
We examined the effects of peroxynitrite pretreatment of pig coronary arteries on their sarcoplasmic reticulum (SR) Ca(2+) pump function. Pretreating rings from de-endothelialized arteries with peroxynitrite, followed by a wash to remove this agent, led to a decrease in the force of contraction produced in response to the SR Ca(2+) pump inhibitor cyclopiazonic acid (CPA, IC(50) = 87 +/- 6 microM). Inclusion of catalase and superoxide dismutase …
Authors
Walia M; Samson SE; Schmidt T; Best K; Kwan CY; Grover AK
Journal
Cell Calcium, Vol. 34, No. 1, pp. 69–74
Publisher
Elsevier
Publication Date
July 2003
DOI
10.1016/s0143-4160(03)00023-x
ISSN
0143-4160
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateAnimalsCalciumCalcium SignalingCalcium-Transporting ATPasesCoronary VesselsEnzyme InhibitorsIndolesIntracellular MembranesMuscle ContractionMuscle, Smooth, VascularNitric OxidePeroxynitrous AcidPotassium ChlorideReperfusion InjurySarcoplasmic ReticulumSuperoxidesSus scrofaVasoconstriction