selected scholarly activity
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books
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chapters
- Glycopeptide antibiotic discovery in the genomic era. Methods in Enzymology. 325-346. 2022
- Antifungal Drugs: The Current Armamentarium and Development of New Agents. 903-922. 2018
- Antifungal Drugs: The Current Armamentarium and Development of New Agents. 903-922. 2017
- d-Ala-d-Ala Carboxypeptidase VanY. 1393-1395. 2013
- Antibiotic Resistome: A Framework Linking the Clinic and the Environment. 15-27. 2011
- The Antibiotic Resistome: Origins, Diversity, and Future Prospects. 165-174. 2011
- Redox Mechanisms and Reactive Oxygen Species in Antibiotic Action and Resistance. 461-471. 2011
- Biochemical Logic of Antibiotic Inactivation and Modification. 81-95. 2009
- Structural Aspects of Aminoglycoside-Modifying Enzymes. 21-33. 2008
- Mechanisms of Aminoglycoside Antibiotic Resistance. 119-140. 2007
- Mechanisms of aminoglycoside antibiotic resistance. 71-101. 2007
- d-Ala-d-Ala carboxypeptidase VanY. 859-860. 2004
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conferences
- The Ying And Yang Of Antibiotic Discovery And Resistance. The FASEB Journal. 2016
- The Ying And Yang Of Antibiotic Discovery And Resistance. The FASEB Journal. 2016
- Biotransformation of anticancer drugs by human and environmental microbiomes. Planta Medica. 863-863. 2015
- The environment as a source of antibiotic resistance. International Journal of Antimicrobial Agents. S15-S15. 2013
- Antibiotic adjuvants: Combining bioactive compounds to overcome resistance. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2013
- Antibiotic resistome: Challenges and opportunities for drug discovery. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012
- A chemical biology approach to probing aminoglycoside phosphotransferase structure and function. Biochemistry and Cell Biology. 193-193. 2008
- A chemical genetic matrix for rational discovery of novel small molecule synergies. Biochemistry and Cell Biology. 195-196. 2008
- A multicomponent platform for elucidating targets of antifungal compounds. Biochemistry and Cell Biology. 186-186. 2008
- Insights into the catalytic mechanism of phosphoheptose isomerase (GmhA), a drug target for combating gram-negative bacterial infection. Biochemistry and Cell Biology. 200-200. 2008
- BIOL 258-Enzymatic resistance to rifamycin antibiotics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2007
- Searching the resistome for new antibiotic resistance mechanisms. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U536-U536. 2005
- Molecular recognition in the adenine-binding region of an aminoglycoside antibiotic kinase.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U172-U172. 2005
- Resistance to aminoglycoside antibiotics: Function meets structure. NOVEL FRONTIERS IN THE PRODUCTION OF COMPOUNDS FOR BIOMEDICAL USE, VOL 1. 85-98. 2001
- Glycopeptide resistance in glycopeptide antibiotic producing organisms.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U1019-U1019. 1999
- Molecular origins of antibiotic resistance. The FASEB Journal. A1426-A1426. 1999
- Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6 '-N-acetyltransferase determined by NMR spectroscopy.. The FASEB Journal. A1305-A1305. 1998
- Aminoglycoside antibiotics. Structures, functions, and resistance. Advances in Experimental Medicine and Biology. 27-69. 1998
- Crystallographic studies of homoserine dehydrogenase for the design of novel antifungal agents. Acta Crystallographica Section A: Foundations of Crystallography. C99-C99. 1996
- Towards unravelling the structure of an antibiotics-inactivating enzyme – kanamycin kinase. Acta Crystallographica Section A: Foundations of Crystallography. C204-C204. 1996
- ARRANGEMENT OF SUBSTRATES AT THE ACTIVE-SITE OF AN AMINOGLYCOSIDE ANTIBIOTIC 3'-PHOSPHOTRANSFERASE (APH(3')-IIIA). The FASEB Journal. A1340-A1340. 1995
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journal articles
- Identification and characterization of the siderochelin biosynthetic gene cluster via coculture.. mBio. 15:e0187124. 2024
- Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae.. Microbial Genomics. 10:001294. 2024
- A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome.. Res Sq. 2024
- Efficacy of aspergillomarasmine A/meropenem combinations with and without avibactam against bacterial strains producing multiple β-lactamases.. Antimicrobial Agents and Chemotherapy. 68:e0027224. 2024
- Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease. Journal of Infectious Diseases. 230:239-249. 2024
- Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease.. Journal of Infectious Diseases. 230:239-249. 2024
- Antibiotic resistance: A key microbial survival mechanism that threatens public health. Cell Host and Microbe. 32:837-851. 2024
- Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes. Nature Communications. 15:4036. 2024
- Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology. 31:760-775.e17. 2024
- Seeing the whole elephant: designing ‘one health’ governance to fight antimicrobial resistance. Clinical Microbiology and Infection (CMI). 30:419-422. 2024
- Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nature Chemical Biology. 20:234-242. 2024
- Angucyclinones rescue PhLOPS A antibiotic activity by inhibiting Cfr-dependent antibiotic resistance. mBio. 14:e0179123. 2023
- Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system. Microbiology spectrum. 11:e0037023. 2023
- Isomerization of bioactive acylhydrazones triggered by light or thiols. Nature Chemistry. 15:1285-1295. 2023
- Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus. Journal of Medicinal Chemistry. 66:9006-9022. 2023
- Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples. Environmental Science and Technology. 57:9713-9721. 2023
- Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221253120. 2023
- Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory. Journal of Industrial Microbiology and Biotechnology. 50:kuad042. 2023
- Canada has an opportunity to address antimicrobial resistance through COVID-19 recovery spending. The Lancet Regional Health - Americas. 16:100393-100393. 2022
- A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling inPseudomonas aeruginosa 2022
- The future of fungi: threats and opportunities. G3: Genes, Genomes, Genetics. 12:jkac224. 2022
- HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics. Molecular Cell. 82:3151-3165.e9. 2022
- Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation. Microbiome. 10:136. 2022
- The past, present, and future of antibiotics. Science Translational Medicine. 14:eabo7793. 2022
- Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. Nature Communications. 13:3634. 2022
- Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. ACS Chemical Biology. 17:1343-1350. 2022
- Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics. ACS Central Science. 8:615-626. 2022
- A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. Cell Chemical Biology. 29:840-853.e6. 2022
- Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Communications Biology. 5:263. 2022
- ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nature Microbiology. 7:451-462. 2022
- Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A. ACS Omega. 7:4170-4184. 2022
- Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society. 143:21127-21142. 2021
- Ancient Antibiotics, Ancient Resistance. EcoSal Plus. 9:eesp-0027-2020. 2021
- Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 118:e2106022118. 2021
- Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. Cell Chemical Biology. 28:1394-1406.e10. 2021
- Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+. Journal of Biological Chemistry. 297:100918-100918. 2021
- CrpP Is Not a Fluoroquinolone-Inactivating Enzyme. Antimicrobial Agents and Chemotherapy. 65:e0077321. 2021
- A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent. ACS Infectious Diseases. 7:1569-1577. 2021
- Coronavirus Disease 2019 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies. Clinical Infectious Diseases. 72:1657-1659. 2021
- The Enzymes of the Rifamycin Antibiotic Resistome. Accounts of Chemical Research. 54:2065-2075. 2021
- The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents. Chemical Reviews. 121:3464-3494. 2021
- ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin. mBio. 12:e02705-e02720. 2021
- Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance. Microbial Genomics. 7. 2021
- Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones. Biochimica et Biophysica Acta - Biomembranes. 1863:183448-183448. 2021
- Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity. ACS Infectious Diseases. 6:3163-3173. 2020
- GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery. Nature Communications. 11:5232. 2020
- Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets. Trends in Molecular Medicine. 26:768-782. 2020
- Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture. mBio. 11:e00449-e00420. 2020
- Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. Scientific Reports. 10:8134. 2020
- Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. Genetics. 214:1103-1120. 2020
- Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner. Antimicrobial Agents and Chemotherapy. 64:e01386-e01319. 2020
- Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature. 578:582-587. 2020
- Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes. Antimicrobial Agents and Chemotherapy. 64:e01324-e01319. 2019
- Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance. Nature Microbiology. 4:1862-1871. 2019
- Antibiotic Dereplication Using the Antibiotic Resistance Platform. Journal of Visualized Experiments. 2019. 2019
- The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor. Applied and Environmental Microbiology. 85:e01292-e01219. 2019
- Environmental and clinical antibiotic resistomes, same only different. Current Opinion in Microbiology. 51:57-63. 2019
- Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics. Nature Biotechnology. 37:1149-1154. 2019
- Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance. Cell Chemical Biology. 26:1333-1334. 2019
- Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology. Journal of Industrial Microbiology and Biotechnology. 46:251-255. 2019
- Drug combinations: a strategy to extend the life of antibiotics in the 21st century. Nature Reviews Microbiology. 17:141-155. 2019
- Heterologous expression-facilitated natural products’ discovery in actinomycetes. Journal of Industrial Microbiology and Biotechnology. 46:415-431. 2019
- Unlocking the potential of natural products in drug discovery. Microbial Biotechnology. 12:55-57. 2019
- Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance. Antimicrobial Agents and Chemotherapy. 62:e01540-e01518. 2018
- Antimicrobial Resistance and Respiratory Infections. Chest. 154:1202-1212. 2018
- Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infectious Diseases. 4:980-987. 2018
- Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. ACS Chemical Biology. 13:1322-1332. 2018
- Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. Cell Chemical Biology. 25:403-412.e5. 2018
- The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. The ISME Journal. 12:885-897. 2018
- Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. ACS Infectious Diseases. 4:135-145. 2018
- Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome. ACS Infectious Diseases. 4:68-76. 2018
- The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nature Communications. 9:112. 2018
- New platform for the discovery of secondary metabolites and the aquaculture application of actinomycete strains isolated from various environments. Anales de la Academia de Ciencias de Cuba. 8. 2018
- Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. ACS Infectious Diseases. 3:955-965. 2017
- Antibiotic resistance: it’s bad, but why isn’t it worse?. Journal of Biology. 15:84. 2017
- Inhibitors of metallo-β-lactamases. Current Opinion in Microbiology. 39:96-105. 2017
- Lessons from the Environmental Antibiotic Resistome. Annual Review of Microbiology. 71:309-329. 2017
- Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. Journal of Antimicrobial Chemotherapy. 72:2297-2303. 2017
- Opportunities for natural products in 21st century antibiotic discovery. Natural product reports (Print). 34:694-701. 2017
- Bacterial proteases, untapped antimicrobial drug targets. Journal of Antibiotics. 70:366-377. 2017
- Combinatorial strategies for combating invasive fungal infections. Virulence. 8:169-185. 2017
- A molecular portrait of maternal sepsis from Byzantine Troy. eLife. 6:e20983. 2017
- Abstract. eLife. 6. 2017
- CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Research (NAR). 45:D566-D573. 2017
- A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell Chemical Biology. 24:98-109. 2017
- A diverse intrinsic antibiotic resistome from a cave bacterium. Nature Communications. 7:13803. 2016
- Evolving medicinal chemistry strategies in antibiotic discovery. Current Opinion in Biotechnology. 42:108-117. 2016
- Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. Chemical Communications. 52:13679-13682. 2016
- Antibiotic Adjuvants: Rescuing Antibiotics from Resistance. Trends in Microbiology. 24:928-928. 2016
- Antibiotic Adjuvants: Rescuing Antibiotics from Resistance. Trends in Microbiology. 24:862-871. 2016
- Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. Cell Chemical Biology. 23:1383-1394. 2016
- Antifungal Drugs: The Current Armamentarium and Development of New Agents. Microbiology spectrum. 4. 2016
- Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships. Angewandte Chemie International Edition. 55:13259-13262. 2016
- Empowering Older Antibiotics. Cell. 167:301-301. 2016
- How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity. ACS Infectious Diseases. 2:642-650. 2016
- The Prehistory of Antibiotic Resistance. Cold Spring Harbor Perspectives in Medicine. 6:a025197-a025197. 2016
- Rifampin phosphotransferase is an unusual antibiotic resistance kinase. Nature Communications. 7:11343. 2016
- Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chemical Biology. 11:864-868. 2016
- Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A. Angewandte Chemie International Edition. 55:2210-2212. 2016
- Antibacterial drug discovery in the resistance era. Nature. 529:336-343. 2016
- Antibiotic Resistance themed issue. MedChemComm. 7:10-10. 2016
- Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. Cell Systems. 1:383-395. 2015
- Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. ACS Infectious Diseases. 1:533-543. 2015
- An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. Cell Reports. 13:1481-1492. 2015
- Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule. ChemBioChem. 16:2498-2506. 2015
- Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Current Opinion in Microbiology. 27:45-50. 2015
- Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11:625-631. 2015
- Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. ACS Infectious Diseases. 1:243-252. 2015
- Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D). Journal of Molecular Biology. 427:2229-2243. 2015
- Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition. ACS Infectious Diseases. 1:175-184. 2015
- Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity. ACS Synthetic Biology. 4:195-206. 2015
- Vancomycin-Variable Enterococci Can Give Rise to Constitutive Resistance during Antibiotic Therapy. Antimicrobial Agents and Chemotherapy. 59:1405-1410. 2015
- Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia. mBio. 6:e02180-e02114. 2015
- Solving the Antibiotic Crisis. ACS Infectious Diseases. 1:80-84. 2015
- An irresistible newcomer. Nature. 517:442-444. 2015
- A macrophage-stimulating compound from a screen of microbial natural products. Journal of Antibiotics. 68:40-46. 2015
- An irresistible newcomer. Nature. 517:442-444. 2015
- Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology. 6:1036. 2015
- Winners of the 2014 JA Medals for excellence. Journal of Antibiotics. 68:1-2. 2015
- Forces shaping the antibiotic resistome. BioEssays. 36:1179-1184. 2014
- Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster. ChemBioChem. 15:2613-2623. 2014
- Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones. Bioorganic and Medicinal Chemistry Letters. 24:4943-4947. 2014
- Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations. Antimicrobial Agents and Chemotherapy. 58:6508-6517. 2014
- The antibiotic resistome: what's new?. Current Opinion in Microbiology. 21:45-50. 2014
- An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria. Journal of Antimicrobial Chemotherapy. 69:1844-1855. 2014
- Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510:503-506. 2014
- A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America. 111:7102-7107. 2014
- Perspective: Synthetic biology revives antibiotics. Nature. 509:S13-S13. 2014
- Winners of the 2013 JA Medals for excellence. Journal of Antibiotics. 67:351-352. 2014
- Something old, something new: revisiting natural products in antibiotic drug discovery. Canadian Journal of Microbiology. 60:147-154. 2014
- Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. Bioorganic and Medicinal Chemistry Letters. 24:905-910. 2014
- Draft genome sequence of the sulfonamide antibiotic-degrading Microbacterium sp. strain C448. Microbiology Resource Announcements. 2. 2014
- Glycopeptide antibiotic biosynthesis. Journal of Antibiotics. 67:31-41. 2014
- Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis. Cell Chemical Biology. 21:136-145. 2014
- Antibiotic resistance—the need for global solutions. The Lancet Infectious Diseases. 13:1057-1098. 2013
- Literature Search and Review. Assay and Drug Development Technologies. 11:509-531. 2013
- Q&A: Antibiotic resistance: what more do we know and what more can we do?. Journal of Biology. 11:51. 2013
- A Cryptic Polyene Biosynthetic Gene Cluster in Streptomyces calvus Is Expressed upon Complementation with a Functional bldA Gene. Cell Chemical Biology. 20:1214-1224. 2013
- Identifying producers of antibacterial compounds by screening for antibiotic resistance. Nature Biotechnology. 31:922-927. 2013
- Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochemical Journal. 454:191-200. 2013
- Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions. International Journal of Medical Microbiology. 303:287-292. 2013
- Self Resistance to the Atypical Cationic Antimicrobial Peptide Edeine of Brevibacillus brevis Vm4 by the N-Acetyltransferase EdeQ. Cell Chemical Biology. 20:983-990. 2013
- Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance inSalmonellaTyphimurium. Proceedings of the National Academy of Sciences of the United States of America. 110:12054-12059. 2013
- Influence of Humans on Evolution and Mobilization of Environmental Antibiotic Resistome. Emerging Infectious Diseases. 19. 2013
- The Comprehensive Antibiotic Resistance Database. Antimicrobial Agents and Chemotherapy. 57:3348-3357. 2013
- How antibiotics kill bacteria: new models needed?. Nature Medicine. 19:544-545. 2013
- Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams. ACS Chemical Biology. 8:226-233. 2013
- Glycopeptide Sulfation Evades Resistance. Journal of Bacteriology. 195:167-171. 2013
- The antibiotic resistance “mobilome”: searching for the link between environment and clinic. Frontiers in Microbiology. 4:138. 2013
- First JA Medal goes to a paper on decalpenic acid. Journal of Antibiotics. 65:591-592. 2012
- Back to the future: a new ‘old’ lead for tuberculosis. EMBO Molecular Medicine. 4:1029-1031. 2012
- Bacterial Inactivation of the Anticancer Drug Doxorubicin. Cell Chemical Biology. 19:1255-1264. 2012
- Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes. Antimicrobial Agents and Chemotherapy. 56:5061-5069. 2012
- A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli. ACS Chemical Biology. 7:1547-1555. 2012
- Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. Proceedings of the National Academy of Sciences of the United States of America. 109:11824-11829. 2012
- Diversity of Integron- and Culture-Associated Antibiotic Resistance Genes in Freshwater Floc. Applied and Environmental Microbiology. 78:4367-4372. 2012
- Antibiotic resistance is ancient: implications for drug discovery. Trends in Microbiology. 20:157-159. 2012
- Determining the mode of action of bioactive compounds. Bioorganic and Medicinal Chemistry. 20:1929-1939. 2012
- Small-Molecule Modulators of Listeria monocytogenes Biofilm Development. Applied and Environmental Microbiology. 78:1454-1465. 2012
- Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes. Biochemistry. 51:1740-1751. 2012
- Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms. Antimicrobial Agents and Chemotherapy. 56:757-764. 2012
- Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome. PLoS ONE. 7:e34953-e34953. 2012
- Antibiotics: A New Hope. Cell Chemical Biology. 19:3-10. 2012
- Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin. MedChemComm. 3:1020-1020. 2012
- The Origins of Antibiotic Resistance. Handbook of Experimental Pharmacology. 211:13-30. 2012
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Palmitoyl‐
dl ‐Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development. ChemBioChem. 12:2759-2766. 2011 - A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome. Cell Chemical Biology. 18:1591-1601. 2011
- Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.. Journal of Biological Chemistry. 286:42786-42786. 2011
- Tackling antibiotic resistance. Nature Reviews Microbiology. 9:894-896. 2011
- Microwave-assisted synthesis of N1- and C3-substituted pyrazolo[3,4-d]pyrimidine libraries. Tetrahedron Letters. 52:5761-5763. 2011
- Antibiotic resistance is ancient. Nature. 477:457-461. 2011
- An ecological perspective of microbial secondary metabolism. Current Opinion in Biotechnology. 22:552-558. 2011
- β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents. Journal of Antibiotics. 64:483-487. 2011
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology. 7:348-350. 2011
- Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase. ChemBioChem. 12:1179-1182. 2011
- Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. FEBS Letters. 585:1061-1066. 2011
- Antibiotic adjuvants: multicomponent anti-infective strategies. Expert Reviews in Molecular Medicine. 13:e5. 2011
- Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Molecular Systems Biology. 7:499. 2011
- Molecular mechanisms of antibiotic resistance. Chemical Communications. 47:4055-4055. 2011
- Receptor domains of two-component signal transduction systems. Molecular Omics. 7:1388-1388. 2011
- Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme. Journal of Biological Chemistry. 286:1966-1975. 2011
- Q&A: Antibiotic resistance: where does it come from and what can we do about it?. Journal of Biology. 8:123. 2010
- The Genomic Enzymology of Antibiotic Resistance. Annual Review of Genetics. 44:25-51. 2010
- Antibiotic resistance in the environment: a link to the clinic?. Current Opinion in Microbiology. 13:589-594. 2010
- Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP. Cell Chemical Biology. 17:959-969. 2010
- The antibiotic resistome. Expert Opinion on Drug Discovery. 5:779-788. 2010
- Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions. ChemBioChem. 11:1325-1334. 2010
- A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. Nature Chemical Biology. 6:327-329. 2010
- Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 fromBacteroides thetaiotaomicron. Acta Crystallographica Section F: Structural Biology Communications. 66:611-614. 2010
- Nucleotide Selectivity of Antibiotic Kinases. Antimicrobial Agents and Chemotherapy. 54:1909-1913. 2010
- Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1. Journal of Antibiotics. 63:177-182. 2010
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Structural and Kinetic Characterization of the LPS Biosynthetic Enzyme
d -α,β-d -Heptose-1,7-bisphosphate Phosphatase (GmhB) from Escherichia coli,. Biochemistry. 49:1033-1041. 2010 - Inactive but not inert. Nature Chemical Biology. 6:85-86. 2010
- The tetracycline resistome. Cellular and Molecular Life Sciences. 67:419-431. 2010
- Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. Phytochemistry. 70:2040-2046. 2009
- Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB. Folding and Design. 17:1649-1659. 2009
- Antimicrobials. Current Opinion in Microbiology. 12:473-475. 2009
- Making Sense of Antisense in Antibiotic Drug Discovery. Cell Host and Microbe. 6:197-198. 2009
- Noncanonical Vancomycin Resistance Cluster from Desulfitobacterium hafniense Y51. Antimicrobial Agents and Chemotherapy. 53:2841-2845. 2009
- Structure and Function of the Glycopeptide N-methyltransferase MtfA, a Tool for the Biosynthesis of Modified Glycopeptide Antibiotics. Cell Chemical Biology. 16:401-410. 2009
- Diversity-Oriented Synthesis and Preliminary Biological Screening of Highly Substituted Five-Membered Lactones and Lactams Originating From an Allyboration of Aldehydes and Imines. ACS Combinatorial Science. 11:155-168. 2009
- Novel approaches to discovery of antibacterial agents. Animal Health Research Reviews. 9:237-246. 2008
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DdlN from Vancomycin-Producing
Amycolatopsis orientalis
C329.2 Is a VanA Homologue with
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preprints