Journal article
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Abstract
The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn2+ metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with distorted octahedral geometry. We report the solid-phase synthesis of 23 novel analogs of AMA involving structural diversification of each subunit (l-Asp, l-APA1, and …
Authors
Koteva K; Sychantha D; Rotondo CM; Hobson C; Britten JF; Wright GD
Journal
ACS Omega, Vol. 7, No. 5, pp. 4170–4184
Publisher
American Chemical Society (ACS)
Publication Date
February 8, 2022
DOI
10.1021/acsomega.1c05757
ISSN
2470-1343