Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance Journal Articles

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abstract

Glycopeptide antibiotics (GPAs) include clinically important drugs used for the treatment of infections caused by Gram-positive pathogens. These antibiotics are specialized metabolites produced by several genera of actinomycete bacteria.

authors

Yim, Grace
Wang, Wenliang
Pawlowski, Andrew C
Wright, Gerard

status

published

publication date

December 2018

has subject area

0605 Microbiology (FoR)
1108 Medical Microbiology (FoR)
1115 Pharmacology and Pharmaceutical Sciences (FoR)
Bacterial Proteins (MeSH)
Drug Resistance, Bacterial (MeSH)
Enterococcus faecalis (MeSH)
Gene Deletion (MeSH)
Glycopeptides (MeSH)
Halogenation (MeSH)
Microbial Sensitivity Tests (MeSH)
Microbiology (Science Metrix)
Molecular Structure (MeSH)
Multigene Family (MeSH)
Ristocetin (MeSH)
Streptomyces (MeSH)
Teicoplanin (MeSH)

published in

Antimicrobial Agents and Chemotherapy Journal