Journal article
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
Abstract
Natural products (NPs) encompass a rich source of bioactive chemical entities. Here, we used human cancer stem cells (CSCs) in a chemical genomics campaign with NP chemical space to interrogate extracts from diverse strains of actinomycete for anti-cancer properties. We identified a compound (McM25044) capable of selectively inhibiting human CSC function versus normal stem cell counterparts. Biochemical and molecular studies revealed that …
Authors
Benoit YD; Mitchell RR; Wang W; Orlando L; Boyd AL; Tanasijevic B; Aslostovar L; Shapovalova Z; Doyle M; Bergin CJ
Journal
Cell Chemical Biology, Vol. 28, No. 10, pp. 1394–1406.e10
Publisher
Elsevier
Publication Date
October 2021
DOI
10.1016/j.chembiol.2021.04.014
ISSN
2451-9456