Unlocking the potential of natural products in drug discovery Journal Articles

abstract

• The natural product specialized metabolites produced by microbes and plants are the backbone of our current drugs. Despite their historical importance, few pharmaceutical companies currently emphasize their exploitation in new drug discovery and instead favour synthetic compounds as more tractable alternatives. Ironically, we are in a Golden Age of understanding of natural product biosynthesis, biochemistry and engineering. These advances have the potential to usher in a new era of natural product exploration and development taking full advantage of the unique and favourable properties of natural products compounds in drug discovery.

authors

• Wright, Gerard

status

• published 

publication date

• January 2019

has subject area

• 0605 Microbiology (FoR)
• Bacteria (MeSH)
• Biological Products (MeSH)
• Biotechnology (MeSH)
• Drug Discovery (MeSH)
• Drug Evaluation, Preclinical (MeSH)
• Metabolic Engineering (MeSH)
• Metabolic Networks and Pathways (MeSH)
• Plants (MeSH)
• Technology, Pharmaceutical (MeSH)

published in

• Microbial Biotechnology  Journal

keywords

• Bacteria
• Biological Products
• Biotechnology
• Drug Discovery
• Drug Evaluation, Preclinical
• Metabolic Engineering
• Metabolic Networks and Pathways
• Plants
• Technology, Pharmaceutical

Digital Object Identifier (DOI)

• 10.1111/1751-7915.13351

start page

• 55

end page

• 57

volume

• 12

issue

• 1