Journal article
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster
Abstract
In this study, a draft genome sequence of Actinoplanes sp. ATCC 53533 was assembled, and an 81-kb biosynthetic cluster for the unusual sulfated glycopeptide UK-68,597 was identified. Glycopeptide antibiotics are important in the treatment of infections caused by Gram-positive bacteria. Glycopeptides contain heptapeptide backbones that are modified by many tailoring enzymes, including glycosyltransferases, sulfotransferases, methyltransferases, …
Authors
Yim G; Kalan L; Koteva K; Thaker MN; Waglechner N; Tang I; Wright GD
Journal
ChemBioChem, Vol. 15, No. 17, pp. 2613–2623
Publisher
Wiley
Publication Date
November 24, 2014
DOI
10.1002/cbic.201402179
ISSN
1439-4227