Journal article
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase
Abstract
The flavin-dependent monooxygenase TetX confers resistance to all clinically relevant tetracyclines, including the recently approved, broad-spectrum antibiotic tigecycline (Tygacil®) which is a critical last-ditch defense against multidrug-resistant pathogens. TetX represents the first resistance mechanism against tigecycline, which circumvents both the tet-gene encoded resistances, relying on active efflux of tetracyclines, and ribosomal …
Authors
Volkers G; Palm GJ; Weiss MS; Wright GD; Hinrichs W
Journal
FEBS Letters, Vol. 585, No. 7, pp. 1061–1066
Publisher
Wiley
Publication Date
April 6, 2011
DOI
10.1016/j.febslet.2011.03.012
ISSN
0014-5793