Journal article
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor
Abstract
Expression of vancomycin resistance genes is known to be controlled by the two-component regulatory system VanRS, but the identity of the VanS receptor ligand has been controversial. Synthesis of a vancomycin photoaffinity probe has now revealed that vancomycin directly binds VanS to induce the expression of resistance genes.
Authors
Koteva K; Hong H-J; Wang XD; Nazi I; Hughes D; Naldrett MJ; Buttner MJ; Wright GD
Journal
Nature Chemical Biology, Vol. 6, No. 5, pp. 327–329
Publisher
Springer Nature
Publication Date
May 2010
DOI
10.1038/nchembio.350
ISSN
1552-4450