Journal article
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance
Abstract
The emergence and spread of carbapenem-resistant Gram-negative pathogens is a global public health problem. The acquisition of metallo-β-lactamases (MBLs) such as NDM-1 is a principle contributor to the emergence of carbapenem-resistant Gram-negative pathogens that threatens the use of penicillin, cephalosporin and carbapenem antibiotics to treat infections. To date, a clinical inhibitor of MBLs that could reverse resistance and re-sensitize …
Authors
King AM; Reid-Yu SA; Wang W; King DT; De Pascale G; Strynadka NC; Walsh TR; Coombes BK; Wright GD
Journal
Nature, Vol. 510, No. 7506, pp. 503–506
Publisher
Springer Nature
Publication Date
6 2014
DOI
10.1038/nature13445
ISSN
0028-0836