Journal article
Determining the mode of action of bioactive compounds
Abstract
Matching bioactive molecules with molecular targets is key to understanding their modes of action (MOA). Moving beyond the mere discovery of drugs, investigators are now just beginning to integrate both biochemical and chemical-genetic approaches for MOA studies. Beginning with simple screens for changes in cell phenotype upon drug treatment, drug bioactivity has been traditionally explored with affinity chromatography, radiolabeling, and …
Authors
Azad MA; Wright GD
Journal
Bioorganic & Medicinal Chemistry, Vol. 20, No. 6, pp. 1929–1939
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.bmc.2011.10.088
ISSN
0968-0896