Journal article
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms
Abstract
The mechanism of high-level resistance to vancomycin in enterococci consists of the synthesis of peptidoglycan terminating in D-alanyl-D-lactate instead of the usual D-alanyl-D-alanine. This alternate cell wall biosynthesis pathway is ensured by the collective actions of three enzymes: VanH, VanA, and VanX. The origin of this resistance mechanism is unknown. We have cloned three genes encoding homologs of VanH, VanA, and VanX from two organisms …
Authors
Marshall CG; Lessard IA; Park I; Wright GD
Journal
Antimicrobial Agents and Chemotherapy, Vol. 42, No. 9, pp. 2215–2220
Publication Date
September 1998
ISSN
0066-4804