Journal article
Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase
Abstract
The streptogramin combination therapy of quinupristin-dalfopristin (Synercid) is used to treat infections caused by bacterial pathogens, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. However, the effectiveness of this therapy is being compromised because of an increased incidence of streptogramin resistance. One of the clinically observed mechanisms of resistance is enzymatic inactivation of …
Authors
Korczynska M; Mukhtar TA; Wright GD; Berghuis AM
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 25, pp. 10388–10393
Publisher
Proceedings of the National Academy of Sciences
Publication Date
June 19, 2007
DOI
10.1073/pnas.0701809104
ISSN
0027-8424