Journal article
Molecular Mechanism of Avibactam-Mediated β‑Lactamase Inhibition
Abstract
Emerging β-lactamase-mediated resistance is threatening the clinical utility of the single most prominent class of antibacterial agents used in medicine, the β-lactams. The diazabicyclooctane avibactam is able to inhibit a wider range of serine β-lactamases than has been previously observed with β-lactamase inhibitors such as the widely prescribed clavulanic acid. However, despite its broad-spectrum activity, variable levels of inhibition have …
Authors
King DT; King AM; Lal SM; Wright GD; Strynadka NCJ
Journal
ACS Infectious Diseases, Vol. 1, No. 4, pp. 175–184
Publisher
American Chemical Society (ACS)
Publication Date
April 10, 2015
DOI
10.1021/acsinfecdis.5b00007
ISSN
2373-8227