Journal article
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+
Abstract
Class B metallo-β-lactamases (MBLs) are Zn2+-dependent enzymes that catalyze the hydrolysis of β-lactam antibiotics to confer resistance in bacteria. Several problematic groups of MBLs belong to subclass B1, including the binuclear New Delhi MBL (NDM), Verona integrin-encoded MBL, and imipenemase-type enzymes, which are responsible for widespread antibiotic resistance. Aspergillomarasmine A (AMA) is a natural aminopolycarboxylic acid that …
Authors
Sychantha D; Rotondo CM; Tehrani KHME; Martin NI; Wright GD
Journal
Journal of Biological Chemistry, Vol. 297, No. 2,
Publisher
Elsevier
Publication Date
August 2021
DOI
10.1016/j.jbc.2021.100918
ISSN
0021-9258