Journal article
The Janus Effect: The Biochemical Logic of Antibiotic Resistance
Abstract
Antibiotics are essential medicines threatened by the emergence of resistance in all relevant bacterial pathogens. The engagement of the molecular targets of antibiotics offers multiple opportunities for resistance to emerge. Successful target engagement often requires passage of the antibiotic from outside into the cell interior through one or two distinct membrane barriers. Resistance can occur by preventing the accumulation of antibiotics in …
Authors
Wright GD
Journal
Biochemistry, Vol. 64, No. 2, pp. 301–311
Publisher
American Chemical Society (ACS)
Publication Date
January 21, 2025
DOI
10.1021/acs.biochem.4c00585
ISSN
0006-2960