Journal article
Crystal Structure of Homoserine Transacetylase from Haemophilus influenzae Reveals a New Family of α/β-Hydrolases † , ‡
Abstract
Homoserine transacetylase catalyzes one of the required steps in the biosynthesis of methionine in fungi and several bacteria. We have determined the crystal structure of homoserine transacetylase from Haemophilus influenzae to a resolution of 1.65 A. The structure identifies this enzyme to be a member of the alpha/beta-hydrolase structural superfamily. The active site of the enzyme is located near the end of a deep tunnel formed by the …
Authors
Mirza IA; Nazi I; Korczynska M; Wright GD; Berghuis AM
Journal
Biochemistry, Vol. 44, No. 48, pp. 15768–15773
Publisher
American Chemical Society (ACS)
Publication Date
December 1, 2005
DOI
10.1021/bi051951y
ISSN
0006-2960