Journal article
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
Abstract
The production of antibiotics by microbes in the environment and their use in medicine and agriculture select for existing and emerging resistance. To address this inevitability, prudent development of antibiotic drugs requires careful consideration of resistance evolution. Here, we identify the molecular basis for expanded substrate specificity in MphI, a macrolide kinase (Mph) that does not confer resistance to erythromycin, in contrast to …
Authors
Pawlowski AC; Stogios PJ; Koteva K; Skarina T; Evdokimova E; Savchenko A; Wright GD
Journal
Nature Communications, Vol. 9, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-017-02680-0
ISSN
2041-1723