Sampling the Antibiotic Resistome Journal Articles

abstract

• Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.

authors

• D'Costa, Vanessa M
• McGrann, Katherine M
• Hughes, Donald W
• Wright, Gerard

status

• published 

publication date

• January 20, 2006

has subject area

• Amino Acid Substitution (MeSH)
• Anti-Bacterial Agents (MeSH)
• Ciprofloxacin (MeSH)
• Daptomycin (MeSH)
• Drug Resistance, Multiple, Bacterial (MeSH)
• Erythromycin (MeSH)
• General Science & Technology (Science Metrix)
• Genes, Bacterial (MeSH)
• Ketolides (MeSH)
• Macrolides (MeSH)
• Microbial Sensitivity Tests (MeSH)
• Molecular Sequence Data (MeSH)
• Mutation (MeSH)
• Rifampin (MeSH)
• Soil Microbiology (MeSH)
• Streptomyces (MeSH)
• Trimethoprim Resistance (MeSH)
• Vancomycin Resistance (MeSH)
• Virginiamycin (MeSH)

published in

• Science  Journal

keywords

• Amino Acid Substitution
• Anti-Bacterial Agents
• Ciprofloxacin
• Daptomycin
• Drug Resistance, Multiple, Bacterial
• Erythromycin
• Genes, Bacterial
• Ketolides
• Macrolides
• Microbial Sensitivity Tests
• Molecular Sequence Data
• Mutation
• Rifampin
• Soil Microbiology
• Streptomyces
• Trimethoprim Resistance
• Vancomycin Resistance
• Virginiamycin

Digital Object Identifier (DOI)

• 10.1126/science.1120800

PubMed ID

• 16424339

start page

• 374

end page

• 377

volume

• 311

issue

• 5759