Journal article
Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance
Abstract
In this issue of Cell Chemical Biology, Radlinski et al. (2019) identify Pseudomonas-derived rhamnolipids that potentiate aminoglycoside antibiotics in the eradication of antibiotic-tolerant bacterial phenotypes. Microbial physiological and mechanistic studies indicate that rhamnolipids permeabilize S. aureus membrane and drive the uptake of aminoglycosides that is independent of proton-motive force.
Authors
Yarlagadda V; Wright GD
Journal
Cell Chemical Biology, Vol. 26, No. 10, pp. 1333–1334
Publisher
Elsevier
Publication Date
October 2019
DOI
10.1016/j.chembiol.2019.09.015
ISSN
2451-9456