Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes Journal Articles

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abstract

Identification of the nucleotide sequences encoding antibiotic resistance elements and determination of their association with antibiotic resistance are critical to improve surveillance and monitor trends in antibiotic resistance. Current methods to study antibiotic resistance in various environments rely on extensive deep sequencing or laborious culturing of fastidious organisms, both of which are heavily time-consuming operations.

authors

Guitor, Allison K
Raphenya, Amogelang R
Klunk, Jennifer
Kuch, Melanie
Alcock, Brian
Surette, Michael
McArthur, Andrew
Poinar, Hendrik
Wright, Gerard

status

published

publication date

December 20, 2019

has subject area

0605 Microbiology (FoR)
1108 Medical Microbiology (FoR)
1115 Pharmacology and Pharmaceutical Sciences (FoR)
Bacteria (MeSH)
DNA Probes (MeSH)
Databases, Genetic (MeSH)
Drug Resistance, Bacterial (MeSH)
Drug Resistance, Multiple, Bacterial (MeSH)
Feces (MeSH)
Gastrointestinal Microbiome (MeSH)
Genome, Bacterial (MeSH)
Humans (MeSH)
Metagenome (MeSH)
Metagenomics (MeSH)
Microbiology (Science Metrix)
Microbiota (MeSH)
Whole Genome Sequencing (MeSH)

published in

Antimicrobial Agents and Chemotherapy Journal