Journal article
Regiospecificity of Aminoglycoside Phosphotransferase from Enterococci and Staphylococci (APH(3‘)-IIIa) †
Abstract
The broad-spectrum aminoglycoside phosphotransferase, APH(3')-IIIa, confers resistance to several aminoglycoside antibiotics in opportunistic pathogens of the genera Staphylococcus and Enterococcus. The profile of the drug resistance phenotype suggested that the enzyme would transfer a phosphate group from ATP to the 3'-hydroxyl of aminoglycosides. In addition, resistance to the 3'-deoxyaminoglycoside antibiotic, lividomycin A, suggested …
Authors
Thompson PR; Hughes DW; Wright GD
Journal
Biochemistry, Vol. 35, No. 26, pp. 8686–8695
Publisher
American Chemical Society (ACS)
Publication Date
January 1, 1996
DOI
10.1021/bi960389w
ISSN
0006-2960