Journal article
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
Abstract
Systematic genetic interaction profiles can reveal the mechanisms-of-action of bioactive compounds. The imipridone ONC201, which is currently in cancer clinical trials, has been ascribed a variety of different targets. To investigate the genetic dependencies of imipridone action, we screened a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout library in the presence of either ONC201 or its more potent …
Authors
Jacques S; van der Sloot AM; Huard CC; Coulombe-Huntington J; Tsao S; Tollis S; Bertomeu T; Culp EJ; Pallant D; Cook MA
Journal
Genetics, Vol. 214, No. 4, pp. 1103–1120
Publisher
Oxford University Press (OUP)
Publication Date
April 1, 2020
DOI
10.1534/genetics.119.302851
ISSN
0016-6731