Medicinal & Biomolecular Chemistry Concept

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• (2S,3S)-Sulfated Pterosin C, a Cytotoxic Sesquiterpene from the Bangladeshi Mangrove FernAcrostichum aureum  Academic Article
• 1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets  Academic Article
• 1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives (Part 1): Action in Ion Channels and GPCRs  Academic Article
• 2-(Oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors  Academic Article
• 2-[F-18] FLUORO-L-DOPA  Conference Paper
• 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones:  Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction  Academic Article
• A 2.13 Å Structure ofE. coliDihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region  Academic Article
• A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines  Academic Article
• A F-18 Labeling Strategy for Near Infrared Fluorophores. Multi-Modal Probes for Reactive Oxygen Species  Conference Paper
• A FAST Pattern Matching Algorithm  Academic Article
• A High-Throughput Screen of the GTPase Activity ofEscherichia coliEngA to Find an Inhibitor of Bacterial Ribosome Biogenesis  Academic Article
• A NEW STRATEGY FOR LABELING BIOMOLECULES THAT CONTAIN DISULFIDE BONDS WITH RHENIUM AND TECHNETIUM  Conference Paper
• A NEW STRATEGY FOR THE PREPARATION AND PURIFICATION OF TC-BASED RADIOPHARMACEUTICALS  Conference Paper
• A New Generation of M(I) Chelates for Correlating in vitro and in vivo Imaging  Conference Paper
• A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin  Academic Article
• A New Strategy for Labeling Unreactive Peptides and Proteins with N-Succinimidyl 4-[F-18]Fluorobenzoate ([F-18]SFB) using water-in-oil microemulsions  Conference Paper
• A Refined Model for the Somatostatin Pharmacophore:  Conformational Analysis of Lanthionine−Sandostatin Analogs  Academic Article
• A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis  Academic Article
• A cell-based approach to characterize antimicrobial compounds through kinetic dose response  Academic Article
• A hybrid solid-fluorous phase radioiodination and purification platform  Academic Article
• A macrophage-stimulating compound from a screen of microbial natural products  Academic Article
• A synthesis of 3-deoxydihydrolycoricidine: Refinement of a structurally minimum pancratistatin pharmacophore  Academic Article
• A tribute to Leo C Vining  Academic Article
• ACHIEVEING HIGH (APPARENT) SPECIFIC ACTIVITY FORMULATIONS USING FLUOROUS-PHASE CHEMISTRY  Conference Paper
• AROMATIC RADIOFLUORINATION WITH [F-18] F2 IN ANHYDROUS HYDROGEN-FLUORIDE  Conference Paper
• Actions of two dopamine derivatives at adreno- and cholinoceptors  Academic Article
• Alginate as an auxiliary bacterial membrane: binding of membrane-active peptides by polysaccharides  Academic Article
• Alginate as an auxiliary bacterial membrane: binding of membrane-active peptides by polysaccharides*  Academic Article
• Allosteric Modulation of the Dopamine D2Receptor by Pro-Leu-Gly-NH2Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation  Academic Article
• Allosteric Modulation of the Dopamine Receptor by Conformationally Constrained Type VI β-Turn Peptidomimetics of Pro-Leu-Gly-NH2  Academic Article
• Allosteric Sensing of Fatty Acid Binding by NMR: Application to Human Serum Albumin  Academic Article
• Analog binding to melatonin receptors in chick brain: Effects of GTP and prazosin  Academic Article
• Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues  Academic Article
• Anti-mesothelioma mechanism of action studies of a complex Cynara scolymus fraction using in silico target prediction and gene expression profiling  Conference Paper
• Antiallergic and antihistaminic effect of two extracts ofCapparis spinosa L. flowering buds  Academic Article
• Antibacterial metabolites from Australian macrofungi from the genus Cortinarius  Conference Paper
• Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4  Academic Article
• Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers  Academic Article
• Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean SpongePhakellia mauritiana1  Academic Article
• Antineoplastic Agents. 380. Isolation and X-ray Crystal Structure Determination of Isoaaptamine from the Republic of SingaporeHymeniacidonsp.and Conversion to the Phosphate Prodrug Hystatin 11  Academic Article
• Apixaban  Academic Article
• Apixaban (vol 33, pg 293, 2008)  Academic Article
• Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells  Academic Article
• Apocynum venetum leaf extract, an antihypertensive herb, inhibits rat aortic contraction induced by angiotensin II: A nitric oxide and superoxide connection  Academic Article
• Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle  Academic Article
• Assay and Drug Development Technologies  Journal
• Assessing the potential of using the Mo-100(p,2n)Tc-99m transformation as a means of producing Curie-quantities of Tc-99m on existing cyclotron infrastructure  Conference Paper
• BAY 43-9006: Early Clinical Data in Patients with Advanced Solid Malignancies  Academic Article
• Bacterial proteases, untapped antimicrobial drug targets  Academic Article
• Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2  Academic Article
• Bioorganic and Medicinal Chemistry  Journal
• Bioorganic and Medicinal Chemistry Letters  Journal
• Biosynthesis of Anosmine: Incorporation of the Intact Six-Carbon Chain of Lysine and of Pipecolic Acid  Academic Article
• Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone  Academic Article
• Biotransformation of anticancer drugs by human and environmental microbiomes  Conference Paper
• CARBORANE DERIVATIVES FOR TARGETING Tc-99m TO NEURORECEPTORS  Conference Paper
• CVT-E002 ACTIVATES HUMAN INNATE IMMUNE RESPONSES VIA SELECTED TOLL-LIKE RECEPTORS  Conference Paper
• Centipeda cunninghamii, an australian traditional medicinal plant  Conference Paper
• ChemMedChem  Journal
• Chemical composition and biological activity of the essential oils from native Australian Callitris species  Conference Paper
• Chemical variation from the neoantimycin depsipeptide assembly line  Academic Article
• Chemistry of Natural Compounds Khimiya Prirodnykh Soedinenii  Journal
• Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology  Book
• Cite and oversight  Academic Article
• Comparative pharmacological study of hydroethanol extracts ofPassiflora alata andPassiflora edulis leaves  Academic Article
• Consideration of Cytokines as Therapeutics Agents or Targets  Academic Article
• Correction to Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors  Academic Article
• Critical role for drug delivery in the development of new ophthalmic treatments  Academic Article
• Current Drug Discovery Technologies  Journal
• Current Medicinal Chemistry  Journal
• Current Opinion in Drug Discovery and Development  Journal
• Current Pharmaceutical Design  Journal
• Current Signal Transduction Therapy  Journal
• Cytokine Therapeutics for Asthma: An Appraisal of Current Evidence and Future Prospects  Academic Article
• Cytokines - Preface  Academic Article
• DIRECT FLUORINATION OF MELATONIN AND 5-HYDROXY-L-TRYPTOPHAN WITH [F-18] F2  Conference Paper
• DISCOVERY AND EVALUATION OF A POTENTIAL MOLECULAR IMAGING AGENT FOR CATHEPSIN B  Conference Paper
• Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA  Academic Article
• Deletion sequences of salmon calcitonin that retain the essential biological and conformational features of the intact molecule  Academic Article
• Design and Synthesis of Photoaffinity-Labeling Ligands of thel-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor  Academic Article
• Design and function of a conformationally restricted analog of the influenza virus fusion peptide  Academic Article
• Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors  Academic Article
• Design, Synthesis, X-ray Analysis, and Dopamine Receptor-Modulating Activity of Mimics of the "C5" Hydrogen-Bonded Conformation in the Peptidomimetic 2-Oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide  Academic Article
• Design, Synthesis, and Dopamine Receptor Modulating Activity of Diketopiperazine Peptidomimetics ofl-Prolyl-l-leucylglycinamide  Academic Article
• Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide  Academic Article
• Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8  Academic Article
• Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8)  Academic Article
• Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites  Academic Article
• Deterioration of storage phosphor screens with use  Academic Article
• Determination of Productive Conformation of Acetylcholinesterase Substrates Using Molecular Mechanics  Academic Article
• Determination of the Fatty Acid Composition of Amygdalus scoparia Kernels from Iran Using Gas Chromatography-Mass Spectrometry  Academic Article
• Determining the mode of action of bioactive compounds  Academic Article
• Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents  Academic Article
• Developments in mitogen-induced extracellular kinase 1 inhibitors and their use in the treatment of disease  Academic Article
• Direct Factor Xa and direct thrombin inhibitors: a clinical trial update.  Academic Article
• Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)  Academic Article
• Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)  Academic Article
• Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies  Academic Article
• Discovery of the Apoptosis-Inducing Activity and High Accumulation of the Butenolides, Menisdaurilide and Aquilegiolide, in Dicentra spectabilis  Academic Article
• Discovery, Synthesis and Antimalarial Evaluation of Natural Product-based Polyamines  Conference Paper
• Do Insecticides have Adverse Effects on Reproduction  Academic Article
• Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function  Academic Article
• Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position  Academic Article
• Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2  Academic Article
• Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2  Academic Article
• Drug Discovery Today  Journal
• Drug evaluation: AP-23573--an mTOR inhibitor for the treatment of cancer.  Academic Article
• Drug evaluation: E-5564.  Academic Article
• Drugs of the Future  Journal
• Effect of a tobacco-related nitrosamine on intercellular communication in human urothelial cells: a possible factor in smoking-related bladder carcinogenesis.  Academic Article
• Emulsion reactors; A new platform for the synthesis of metal-based molecularimaging agents  Conference Paper
• Enzymatic synthesis of (−)-6-[18F]-fluoronorepinephrine from 6-[18F]-fluorodopamine by dopamine β-hydroxylase  Academic Article
• Erratum to “Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA” [Bioorg. Med. Chem. Lett. 23 (2013) 2426–2431]  Academic Article
• European Journal of Medicinal Chemistry  Journal
• Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers  Academic Article
• Evidences for direct action of diethylcarbamazine on the Brugia malayi adult worm: immunoreactivity pattern of adult worms exposed to DEC in vitro and in vivo.  Academic Article
• Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds  Academic Article
• Experimental Screening of Dihydrofolate Reductase Yields a “Test Set” of 50,000 Small Molecules for a Computational Data-Mining and Docking Competition  Academic Article
• Expert Opinion on Therapeutic Patents  Journal
• Exploring the awareness of research among registered massage therapists in Ontario  Academic Article
• Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy  Academic Article
• F-18 LABELED XENON DIFLUORIDE  Conference Paper
• FLUORINE-18 LABELLED AROMATIC AMINO ACIDS FOR TUMOR IMAGING USING PET  Conference Paper
• Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion  Academic Article
• First JA Medal goes to a paper on decalpenic acid  Academic Article
• Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv  Academic Article
• Future Medicinal Chemistry  Journal
• Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials  Academic Article
• Gene Vectors for Cytokine Expression In Vivo  Academic Article
• Ginkgo biloba extract for essential hypertension: A systemic review  Academic Article
• Global Gastrointestinal Safety Profile of Etoricoxib and Lumiracoxib  Academic Article
• Glycopeptide antibiotic biosynthesis  Academic Article
• Growth hormone-releasing factor analogs with hydrophobic residues at position 19. Effects on growth hormone releasing activity in vitro and in vivo, stability in blood plasma in vitro, and secondary structure  Academic Article
• High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate  Academic Article
• Human Cytochrome P450 Liability Studies oftrans-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell Growth Inhibitor  Academic Article
• Hydrophobic Interactions in Complexes of Antimicrobial Peptides with Bacterial Polysaccharides  Academic Article
• IDrugs : the investigational drugs journal  Journal
• ISO-STRUCTURAL FLUORESCENT AND Tc-99m PROBES FOR LABELING BIOMOLECULES  Conference Paper
• Identification of Small Molecule Chemical Inhibitors of the Collagen-Specific Chaperone Hsp47  Academic Article
• Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity  Academic Article
• Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches  Academic Article
• Ilodecakin. Schering-Plough Corp.  Academic Article
• Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry  Journal
• In Vitro Screening for Drug Repositioning  Academic Article
• In vitro biomass of Salvia corrugata: chemical analysis and evaluation of antimicrobial activity  Conference Paper
• In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato  Academic Article
• Incorporation of an inducible nucleotide analog into DNA by DNA polymerases  Academic Article
• Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition  Academic Article
• Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1  Academic Article
• Informatic search for natural products (iSNAP) - A dereplication and discovery tool  Conference Paper
• Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones  Academic Article
• Inhibitors of Bacterial Cystathionine β-Lyase:  Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function  Academic Article
• Intedanib, a triple kinase inhibitor of VEGFR, FGFR and PDGFR for the treatment of cancer and idiopathic pulmonary fibrosis.  Academic Article
• Interaction of Calcium Channel Antagonists with Calcium: Structural Studies on Nicardipine and Its Ca2+ Complex  Academic Article
• Interaction of calcium channel antagonists with calcium: spectroscopic and modeling studies on diltiazem and its Ca2+ complex  Academic Article
• Interaction of calcium channel antagonists with calcium: structural studies on verapamil and its Ca2+ complex  Academic Article
• Interaction of gonadotropin-releasing hormone and its agonist analogs with Ca2+ in a nonpolar milieu. Correlation with biopotencies  Academic Article
• Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)  Academic Article
• Isolation of Novel Cytotoxic Compounds from a Bangladeshi Medicinal Plant Acrostichum aureum  Conference Paper
• Isolation of flavonoids from apple peel using novel graphene oxide cotton fiber  Academic Article
• Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine  Academic Article
• Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.  Academic Article
• Isotopic labelling in mass spectrometry as a tool for studying reaction mechanisms of ion dissociations  Academic Article
• Japanese Journal of Antibiotics Journal of Antibiotics  Journal
• Journal of Biomolecular Screening  Journal
• Journal of Chemical Information and Computer Sciences Journal of Chemical Information and Modeling  Journal
• Journal of Complementary and Integrative Medicine  Journal
• Journal of Computer-Aided Molecular Design Perspectives in Drug Discovery and Design  Journal
• Journal of Ethnopharmacology  Journal
• Journal of Labelled Compounds and Radiopharmaceuticals  Journal
• Journal of Medicinal Chemistry Journal of Medicinal and Pharmaceutical Chemistry  Journal
• Journal of Natural Products  Journal
• Journal of Peptide Research Peptide Research Chemical Biology and Drug Design  Journal
• Lanthionine−Somatostatin Analogs:  Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies  Academic Article
• Left Ventricular Non-compaction: From Recognition to Treatment  Academic Article
• Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes  Academic Article
• Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.  Academic Article
• Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators  Academic Article
• Medicinal Chemistry Research  Journal
• Medicinal Research Reviews  Journal
• Mini-Reviews in Medicinal Chemistry  Journal
• Modifier Gene Studies to Identify New Therapeutic Targets in Cystic Fibrosis  Academic Article
• Modulation of Salmonella gene expression by subinhibitory concentrations of quinolones  Academic Article
• Molecular Dynamics of Fibrinogen Adsorption onto Graphene, but Not onto Poly(ethylene glycol) Surface, Increases Exposure of Recognition Sites That Trigger Immune Response  Academic Article
• Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides  Academic Article
• N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin  Academic Article
• Natural Product Research Natural Product Letters  Journal
• New Anticoagulants for the Prevention of Thromboembolism  Academic Article
• New phenolic inhibitors of yeast homoserine dehydrogenase  Academic Article
• Novel HldE-K Inhibitors Leading to Attenuated Gram Negative Bacterial Virulence  Academic Article
• Oncology Research Anti-Cancer Drug Design  Journal
• One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii  Academic Article
• Opinion: Direct-to-consumer advertising of prescription medicines: a counter argument  Academic Article
• Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation  Academic Article
• Ovarian Toxicity of Environmental Toxicants  Academic Article
• Pancratistatin Selectively Induces Apoptosis in Cancer Cells and Reduces Growth of Colon Xenografts  Conference Paper
• Pharmaceutical Biology  Journal
• Pharmacologic Properties of the New Oral Anticoagulants: A Clinician-oriented Review with a Focus on Perioperative Management  Academic Article
• Pharmacology and Clinical Potential of Direct Thrombin Inhibitors  Academic Article
• Phototoxic Furanoquinolines of the Rutaceae  Academic Article
• Phytomedicine  Journal
• Phytotherapy Research  Journal
• Planta Medica  Journal
• Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors  Academic Article
• Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs  Academic Article
• Preparation and Evaluation of Carborane Analogues of Tamoxifen  Academic Article
• Preparation and Evaluation of Fluorine-18-Labeled Insulin as a Molecular Imaging Probe for Studying Insulin Receptor Expression in Tumors  Academic Article
• Preparation and Evaluation of Halogenated and Metallated Cathepsin B Inhibitors as Molecular Imaging Agents  Conference Paper
• Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy  Academic Article
• Preparation and evaluation of reagents for tagging amino and thiol groups with fluorous stannanes. A convenient method for producing radioiodinated compounds in high effective specific activity  Academic Article
• Preparation of labelled 2-methoxy-3-alkylpyrazines: synthesis and characterization of deuterated 2-methoxy-3-isopropylyrazine and 2-methoxy-3-isobutylpyrazine  Academic Article
• Preparation of technetium-99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods  Academic Article
• Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors  Academic Article
• Production of new polyene antibiotics by Streptomyces cellulosae after addition of ethyl(Z)-16-phenylhexadec-9-enoate.  Academic Article
• Proteasome-mediated proteostasis: Novel medicinal and pharmacological strategies for diseases  Academic Article
• Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development  Academic Article
• Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase  Academic Article
• QSAR and Combinatorial Science Quantitative Structure-Activity Relationships Molecular Informatics  Journal
• Quantum Mechanics/Molecular Mechanics Strategies for Docking Pose Refinement: Distinguishing between Binders and Decoys in Cytochrome c Peroxidase  Academic Article
• RADIOFLUORINATION OF L-THREO-3-(3,4-DIHYDROXYPHENYL)SERINE: SYNTHESIS OF POTENTIAL F-18 LABELLED PET TRACERS FOR NOREPINEPHRINE  Conference Paper
• RADIOFLUORINATION WITH XENON DIFLUORIDE - L-6[F-18]FLUORO-DOPA  Conference Paper
• REGIO- AND STEREOSELECTIVE ELECTROPHILIC FLUORINATION OF 3,4,6-TRI-O-ACETYL-D-GLUCAL (TAG) IN ACIDIC MEDIUM  Conference Paper
• RSC-SCI--tenth medicinal chemistry symposium. 5-8 September 1999, Churchill College, Cambridge, UK.  Academic Article
• Radiosensitization of Colon Cancer Cell Lines by Docetaxel: Mechanisms of Action  Academic Article
• Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput Screening  Academic Article
• Re-evaluation of Fibrogenic Cytokines in Lung Fibrosis  Academic Article
• Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns  Academic Article
• Residual Vein Thrombosis and D-Dimer for Optimizing Duration of Anticoagulation in Idiopathic Deep Vein Thrombosis  Academic Article
• Reversing Anticoagulant Therapy  Academic Article
• Role of DAP12 in Innate and Adaptive Immune Responses  Academic Article
• Role of Dendritic Cell-Derived Cytokines in Immune Regulation  Academic Article
• SYNTHESIS OF 18F-RADIOTRACERS IN HIGH SPECIFIC ACTIVITY USING THE FLUOROUS APPROACH  Conference Paper
• SYNTHESIS, ANTIFUNGAL AND ANTI-BACTERIAL ACTIVITY OF AMINOALKYL KETONES IN SULFUR HETEROCYCLIC SERIES  Academic Article
• SYNTHESIS, RADIOLABELLING AND BIOLOGICAL EVALUATION OF TARGETED METALLACARBORANE (M=99MTc) DERIVATIVES FOR IMAGING NEURORECEPTORS  Conference Paper
• Safety and Efficacy of Ximelagatran: Meta-Analysis of the Controlled Randomized Trials for the Prophylaxis or Treatment of Venous Thromboembolism  Academic Article
• Screening in Academe: A Perspective on Implementation of University-Based Small Molecule Screening  Academic Article
• Screening of ligands for redox-active europium using magnetic resonance imaging  Academic Article
• Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids  Academic Article
• Side chain flexibility and the pore dimensions in the GABAA receptor  Academic Article
• Single amino acid chelate complexes of the M(CO)3+core for correlating fluorescence and radioimaging studies (M = 99mTc or Re)  Academic Article
• Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine  Academic Article
• Small molecule immunomodulins from cultures of the human microbiome member Lactobacillus plantarum  Academic Article
• Solving the Supply of Resveratrol Tetramers from Papua New Guinean Rainforest Anisoptera Species That Inhibit Bacterial Type III Secretion Systems  Academic Article
• Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones  Academic Article
• Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties  Academic Article
• Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55  Academic Article
• Structure–activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis  Academic Article
• Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids  Academic Article
• Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4  Academic Article
• Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore  Academic Article
• Synthesis and Biological Activity of a Focused Library of Mitogen-activated Protein Kinase Phosphatase Inhibitors  Academic Article
• Synthesis and Biological Evaluation of Fully Functionalizedseco-Pancratistatin Analogues§  Academic Article
• Synthesis and Characterization of Rhenium and Technetium-99m Labeled Insulin  Academic Article
• Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide  Academic Article
• Synthesis and Dopamine Receptor Modulating Activity of Novel Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide Featuring α,α-Disubstituted Amino Acids  Academic Article
• Synthesis and Dopamine Receptor Modulating Activity of Substituted Bicyclic Thiazolidine Lactam Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide  Academic Article
• Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation  Academic Article
• Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B  Academic Article
• Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor  Academic Article
• Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide  Academic Article
• Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases  Academic Article
• Synthesis and antifilarial evaluation of N1,N n- xylofuranosylated diaminoalkanes  Academic Article
• Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue  Academic Article
• Synthesis and characterisation of13C and15N isotopomers of a 1-acyl-7-nitroindoline  Academic Article
• Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs of Pro-Leu-Gly-NH2  Academic Article
• Synthesis and dopamine receptor modulating activity of unsubstituted and substituted triproline analogues of l-prolyl-l-leucyl-glycinamide (PLG)  Academic Article
• Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-45014DM)  Academic Article
• Synthesis and in Vitro Evaluation of18F- and19F-Labeled Insulin:  A New Radiotracer for PET-based Molecular Imaging Studies  Academic Article
• Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)  Academic Article
• Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities.  Academic Article
• Synthesis of Pro-Leu-Gly-NH2 analogs modified at the prolyl residue and evaluation of their effects on the receptor binding activity of the central dopamine receptor agonist, ADTN  Academic Article
• Synthesis of cholesteryl esters of labelled fatty acids  Academic Article
• Synthesis of f-18 labelled fluoro-melatonins and 5-hydroxy-fluoro-tryptophans  Academic Article
• Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors  Academic Article
• Synthetic Glucocorticoids: Antenatal Administration and Long-term Implications  Academic Article
• Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies  Academic Article
• TEMPERATURE EFFECT ON THE STEREOSPECIFICITY OF NUCLEOPHILIC FLUORINATION: FORMATION OF [18F]TRANS-4-FLUORO-L-PROLINE DURING THE SYNTHESIS OF [18F]CIS-4-FLUORO-L-PROLINE  Conference Paper
• THE PREPARATION AND IN VITRO EVALUATION OF CARBORANE SELECTIVE ESTROGEN RECEPTOR MODULATORS  Conference Paper
• Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics  Academic Article
• Temperature effects on the stereospecificity of nucleophilic fluorination: formation of trans-[18F]4-fluoro-l-proline during the synthesis of cis-[18F]4-fluoro-l-proline  Academic Article
• The AMP-Activated Protein Kinase: Role in Regulation of Skeletal Muscle Metabolism and Insulin Sensitivity  Academic Article
• The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction  Academic Article
• The Development of New Factor Xa Inhibitors Based on Amide Synthesis  Academic Article
• The Effects of Commercial Preparations of Herbal Supplements Commonly Used by Women on the Biotransformation of Fluorogenic Substrates by Human Cytochromes P450  Academic Article
• The First Organometallic Selective Estrogen Receptor Modulators (SERMs) and Their Relevance to Breast Cancer  Academic Article
• The Hunt for New Tuberculosis Vaccines: Anti-TB Immunity and Rational Design of Vaccines  Academic Article
• The Identification of 5-Hydroxyl-L-norvaline in Cultures of Pyridoxine Auxotrophs of Escherichia coli B  Academic Article
• The Nervous System as a Critical Regulator of Immune Responses Underlying Allergy  Academic Article
• The Role of IL-15 Signaling in the Induction of Innate Antiviral Responses  Academic Article
• The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor  Academic Article
• The effects of different concentrations of saffron (Crocus sativus) decoction on preterm delivery in mice  Conference Paper
• The new potent immunosuppressant FK-506 reverses multidrug resistance in Chinese hamster ovary cells.  Academic Article
• The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.  Academic Article
• Therapeutic Peptides: New Arsenal Against Drug Resistant Pathogens  Academic Article
• Therapeutic advances in the treatment of osteoporosis  Academic Article
• Therapeutic approaches for haemophilia  Academic Article
• Therapeutic patents for the treatment of premenstrual syndrome and premenstrual dysphoric disorder: historical perspectives and future directions  Academic Article
• Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase  Academic Article
• Three new polyketides from fruiting bodies of the endophytic ascomycete Xylaria polymorpha  Academic Article
• Tifacogin (Chiron Corp/Pharmacia Corp).  Academic Article
• Triazole Appending Agent (TAAG): A new hydrophilic iodine-containing prosthetic group for the preparation of targeted radiopharmaceuticals  Conference Paper
• Trifluoromethanesulfonic acid, an alternative solvent medium for the direct electrophilic fluorination of DOPA: new syntheses of 6-[18F]fluoro-L-DOPA and 6-[18F]fluoro-D-DOPA  Academic Article
• Triggering of Erythrocyte Cell Membrane Scrambling by Ursolic Acid  Academic Article
• Tris(3-hydroxypropyl)phosphine (THPP): A mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides  Academic Article
• Using chemical bonds to analyze data retrieved from the inorganic crystal structure database  Academic Article
• Winners of the 2013 JA Medals for excellence  Academic Article
• Winners of the 2014 JA Medals for excellence  Academic Article
• eta(5)-TYPE ORGANOMETALLIC COMPOUNDS AND THE PREPARATION OF Tc RADIOTRACERS  Conference Paper
• iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide  Academic Article
• β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents  Academic Article
• “Just don’t be creepy”: A phenomenological study of the experiences of men in massage therapy  Academic Article