Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes Academic Article uri icon

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abstract

  • The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

authors

  • Budriesi, R
  • Ioan, P
  • Carosati, E
  • Cruciani, G
  • Zhorov, Boris
  • Chiarini, A

publication date

  • October 1, 2009