Journal article
Synthesis of f‐18 labelled fluoro‐melatonins and 5‐hydroxy‐fluoro‐tryptophans
Abstract
Abstract Reaction of dilute [F‐18]fluorine gas with either melatonin or 5‐hydroxy‐tryptophan in hydrogen fluoride at −70°C gives 6‐fluoro‐melatonin or 4‐ and 6‐fluoro‐5‐hydroxytryptophan. They are of potential use in Positron Emission Tomography to image the binding sites for melatonin and to study the metabolism of serotonin.
Authors
Chirakal R; Sayer BG; Firnau G; Garnett ES
Journal
Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 25, No. 1, pp. 63–71
Publisher
Wiley
Publication Date
January 1988
DOI
10.1002/jlcr.2580250108
ISSN
0362-4803