Journal article
Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55
Abstract
Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.
Authors
Li X; Zvanych R; Torchia J; Magarvey NA
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 14, pp. 4150–4153
Publisher
Elsevier
Publication Date
7 2013
DOI
10.1016/j.bmcl.2013.05.042
ISSN
0960-894X