Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55 Academic Article uri icon

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abstract

  • Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.

publication date

  • July 2013