Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean SpongePhakellia mauritiana1 Academic Article uri icon

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abstract

  • Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.

authors

  • Pettit, George R
  • Mcnulty, James
  • Herald, Delbert L
  • Doubek, Dennis L
  • Chapuis, Jean-Charles
  • Schmidt, Jean M
  • Tackett, Larry P
  • Boyd, Michael R

publication date

  • February 1997