Journal of Medicinal Chemistry
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Overview
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Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes.
67:1209-1224.
2024
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Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus.
66:9006-9022.
2023
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Tetrazine-Derived Near-Infrared Dye for Targeted Photoacoustic Imaging of Bone.
66:6025-6036.
2023
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Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma.
65:3193-3217.
2022
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Synthesis and Preclinical Evaluation of [18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model.
64:15671-15689.
2021
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Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
64:13540-13550.
2021
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Imaging of Fibroblast Activation Protein in Cancer Xenografts Using Novel (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine-Based Small Molecules.
64:4059-4070.
2021
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Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
63:4762-4775.
2020
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Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators.
62:5063-5079.
2019
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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
62:2651-2665.
2019
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A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin.
60:8358-8368.
2017
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A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines.
59:9381-9389.
2016
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Allosteric Sensing of Fatty Acid Binding by NMR: Application to Human Serum Albumin.
59:7457-7465.
2016
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Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy.
59:2660-2673.
2016
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Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B.
57:9564-9577.
2014
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Preparation and Evaluation of Fluorine-18-Labeled Insulin as a Molecular Imaging Probe for Studying Insulin Receptor Expression in Tumors.
57:3678-3686.
2014
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A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors.
56:7902-7910.
2013
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Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography.
56:6696-6708.
2013
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Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties.
56:1405-1417.
2013
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Correction to Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors.
54:8712-8712.
2011
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Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors.
54:3360-3367.
2011
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Preparation and Evaluation of Carborane Analogues of Tamoxifen.
53:8012-8020.
2010
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Synthesis and Characterization of Rhenium and Technetium-99m Labeled Insulin.
53:2612-2621.
2010
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Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues.
52:3982-3993.
2009
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Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation.
52:2043-2051.
2009
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Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor.
51:2833-2844.
2008
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Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide.
51:1791-1799.
2008
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Allosteric Modulation of the Dopamine Receptor by Conformationally Constrained Type VI β-Turn Peptidomimetics of Pro-Leu-Gly-NH2.
50:6725-6729.
2007
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Inhibitors of Bacterial Cystathionine β-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function.
50:755-764.
2007
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A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region.
49:6977-6986.
2006
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Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases.
49:5273-5281.
2006
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Synthesis and in Vitro Evaluation of18F- and19F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies.
49:1466-1474.
2006
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Design and Synthesis of Photoaffinity-Labeling Ligands of thel-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor.
49:307-317.
2006
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Identification of Small Molecule Chemical Inhibitors of the Collagen-Specific Chaperone Hsp47.
48:1680-1684.
2005
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4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction.
46:2819-2822.
2003
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Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide.
46:727-733.
2003
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Synthesis and Dopamine Receptor Modulating Activity of Substituted Bicyclic Thiazolidine Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide.
42:2977-2987.
1999
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Synthesis and Dopamine Receptor Modulating Activity of Novel Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide Featuring α,α-Disubstituted Amino Acids.
42:1441-1447.
1999
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Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide.
42:628-637.
1999
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Design, Synthesis, and Dopamine Receptor Modulating Activity of Diketopiperazine Peptidomimetics ofl-Prolyl-l-leucylglycinamide.
40:3594-3600.
1997
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A Refined Model for the Somatostatin Pharmacophore: Conformational Analysis of Lanthionine−Sandostatin Analogs.
40:2252-2258.
1997
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Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies.
40:2241-2251.
1997
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Interaction of Calcium Channel Antagonists with Calcium: Structural Studies on Nicardipine and Its Ca2+ Complex.
37:4392-4399.
1994
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Design, Synthesis, X-ray Analysis, and Dopamine Receptor-Modulating Activity of Mimics of the "C5" Hydrogen-Bonded Conformation in the Peptidomimetic 2-Oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide.
37:3677-3683.
1994
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Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2.
36:3481-3483.
1993
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Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2.
36:2356-2361.
1993
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Interaction of calcium channel antagonists with calcium: spectroscopic and modeling studies on diltiazem and its Ca2+ complex.
36:1324-1332.
1993
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Interaction of calcium channel antagonists with calcium: structural studies on verapamil and its Ca2+ complex.
36:1017-1023.
1993
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Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs of Pro-Leu-Gly-NH2.
36:256-263.
1993
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Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue.
33:1828-1832.
1990
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Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2.
31:1430-1436.
1988
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Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position.
29:2100-2104.
1986
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Synthesis of Pro-Leu-Gly-NH2 analogs modified at the prolyl residue and evaluation of their effects on the receptor binding activity of the central dopamine receptor agonist, ADTN.
29:2104-2107.
1986
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Actions of two dopamine derivatives at adreno- and cholinoceptors.
22:117-119.
1979
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