Antimitotic and cell growth inhibitory properties...

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

Abstract

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.

Authors

Lawrence NJ; Rennison D; Woo M; McGown AT; Hadfield JA

Journal

Bioorganic & Medicinal Chemistry Letters, Vol. 11, No. 1, pp. 51–54

Publisher

Elsevier

Publication Date

January 8, 2001

DOI

10.1016/s0960-894x(00)00596-5

ISSN

0960-894X

Associated Experts

Ming-ko Woo

Professor Emeritus, Faculty of Science

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