Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers Journal Articles

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abstract

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.

authors

Lawrence, Nicholas J
Rennison, David
Woo, Ming-ko
McGown, Alan T
Hadfield, John A

status

published

publication date

January 2001

has subject area

0304 Medicinal and Biomolecular Chemistry (FoR)
0305 Organic Chemistry (FoR)
1115 Pharmacology and Pharmaceutical Sciences (FoR)
Antineoplastic Agents (MeSH)
Antineoplastic Agents, Phytogenic (MeSH)
Cell Cycle (MeSH)
Cell Division (MeSH)
Colchicine (MeSH)
Ethers (MeSH)
Humans (MeSH)
Inhibitory Concentration 50 (MeSH)
Medicinal & Biomolecular Chemistry (Science Metrix)
Molecular Structure (MeSH)
Plants, Medicinal (MeSH)
Protein Binding (MeSH)
Stilbenes (MeSH)
Tubulin (MeSH)
Tumor Cells, Cultured (MeSH)

published in

Bioorganic and Medicinal Chemistry Letters Journal