Journal article
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
Abstract
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
Authors
Lawrence NJ; Rennison D; Woo M; McGown AT; Hadfield JA
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 11, No. 1, pp. 51–54
Publisher
Elsevier
Publication Date
January 2001
DOI
10.1016/s0960-894x(00)00596-5
ISSN
0960-894X