Journal article
Tris(3-hydroxypropyl)phosphine (THPP): A mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides
Abstract
Tris(3-hydroxypropyl)phosphine (THPP) is demonstrated to be a versatile, water-soluble and air-stable reducing agent, allowing for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous-organic media. The reagent shows exceptional stability at biological pH under which condition it permits the rapid reduction of a wide range of differentially functionalized small-molecule disulfides.
Authors
McNulty J; Krishnamoorthy V; Amoroso D; Moser M
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 19, pp. 4114–4117
Publisher
Elsevier
Publication Date
October 2015
DOI
10.1016/j.bmcl.2015.08.027
ISSN
0960-894X