Journal article
Synthesis and in Vitro Evaluation of 18F- and 19F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies
Abstract
A new and regioselective strategy was developed for the preparation of fluorine-18-labeled insulin as a novel positron emission tomography (PET) tracer. [18F]-4-Fluorobenzoic acid (4-18FBA), which was produced in 83 +/- 8% yield (n = 10), through the use of succinimidyl [18F]-4-fluorobenzoate (4-(18)FSB), was conjugated through a short spacer (6-aminohexanoic acid, AHx) to the PheB1 residue of a protected form of insulin. 18FB-AHx-insulin (8b) …
Authors
Guenther KJ; Yoganathan S; Garofalo R; Kawabata T; Strack T; Labiris R; Dolovich M; Chirakal R; Valliant JF
Journal
Journal of Medicinal Chemistry, Vol. 49, No. 4, pp. 1466–1474
Publisher
American Chemical Society (ACS)
Publication Date
February 1, 2006
DOI
10.1021/jm0509344
ISSN
0022-2623