Journal article
Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone
Abstract
Macrocyclization of polyketides generates arrays of molecular architectures that are directly linked to biological activities. The four-membered ring in oxetanones (β-lactones) is found in a variety of bioactive polyketides (for example, lipstatin, hymeglusin and ebelactone), yet details of its molecular assembly have not been extensively elucidated. Using ebelactone as a model system, and its producer Streptomyces aburaviensis ATCC 31860, …
Authors
Wyatt MA; Ahilan Y; Argyropoulos P; Boddy CN; Magarvey NA; Harrison PH
Journal
The Journal of Antibiotics, Vol. 66, No. 7, pp. 421–430
Publisher
Springer Nature
Publication Date
July 2013
DOI
10.1038/ja.2013.48
ISSN
0021-8820