Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge Verongula rigida Academic Article uri icon

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abstract

  • The natural product veranamine was isolated from the marine sponge Verongula rigida. It contains a unique heterocyclic scaffold and demonstrates in vivo antidepressant activity and selective affinity for 5HT2B and sigma-1 receptors. The first total synthesis of veranamine is reported. Our scalable synthesis offers veranamine in six steps and 25% yield via an unprecedented vinylogous Pictet-Gams pyridine formation strategy. Veranamine is a promising new lead compound for antidepressant drug development.

authors

  • Kochanowska-Karamyan, Anna J
  • Araujo, Hugo C
  • Zhang, Xiong
  • El-Alfy, Abir
  • Carvalho, Paulo
  • Avery, Mitchell A
  • Holmbo, Stephen D
  • Magolan, Jakob
  • Hamann, Mark T

publication date

  • April 24, 2020