Journal article
One Solution for All: Searching for Universal Aptamers for Constantly Mutating Spike Proteins of SARS‐CoV‐2
Abstract
Aptamers that can recognize the spike (S) protein of SARS-CoV-2 with high affinity and specificity are useful molecules towards the development of diagnostics and therapeutics to fight COVID-19. However, this S protein is constantly mutating, producing variants of concern (VoCs) that can significantly weaken the binding by aptamers initially engineered to recognize the S protein of the wildtype virus or a specific VoC. One strategy to overcome …
Authors
Li J; Zhang Z; Amini R; Li Y
Journal
ChemMedChem, Vol. 17, No. 13,
Publisher
Wiley
Publication Date
July 5, 2022
DOI
10.1002/cmdc.202200166
ISSN
1860-7179