Journal article
An Endogenous Reactive Oxygen Species (ROS)‐Activated Histone Deacetylase Inhibitor Prodrug for Cancer Chemotherapy
Abstract
Suberoylanilide hydroxamic acid (SAHA, vorinostat) is a potent small-molecule pan-inhibitor of histone deacetylases (HDACs) approved for treatment of cutaneous T-cell lymphoma (CTCL). However, SAHA exhibits poor selectivity for cancer cells over noncancer cells. With an aim to improving its selectivity for cancer cells, we generated a novel SAHA prodrug (SAHA-OBP) that is activated in the presence of hydrogen peroxide, a reactive oxygen species …
Authors
Bhagat SD; Singh U; Mishra RK; Srivastava A
Journal
ChemMedChem, Vol. 13, No. 19, pp. 2073–2079
Publisher
Wiley
Publication Date
October 8, 2018
DOI
10.1002/cmdc.201800367
ISSN
1860-7179